Section of livers and kidneys were excised and fixed in 10% formalin for histopathology examination. 3rd ed. PubMed If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Chemical constituents and biological activities of species of Justicia a review. Justicia pectoralis is a flowering herb that grows in tropical areas of the Americas, including South and Central America. The reaction is terminated by the addition of 2ml of dichromoacetic acid mixture (potassium dichromate (5%) and glacial acetic acid; 1:3v/v) and heated at 60C for 10min. From this study, the significant increase in platelet counts suggested that the extract could be useful in preventing excessive blood loss (through blood clotting) and resistance of capillary membranes to leakage of red cells when blood vessels are damaged. volume7, Articlenumber:2 (2021) Locklear, T. D., Huang, Y., Frasor, J., Doyle, B. J., Perez, A., Gomez-Laurito, J., and Mahady, G. B. Estrogenic and progestagenic effects of extracts of Justicia pectoralis Jacq., an herbal medicine from Costa Rica used for the treatment of menopause and PMS. Omogunwa is a graduate of Biochemistry from the Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. WBC reduced in rats treated with doses of J. carnea with significant decrease (p<0.05) in rats that received 50, 100 and 1200mg/kg body weight. It is also composed of vitamins and minerals good for heart health. One of the symptoms of diabetes is elevated blood glucose level. The effect of the ethanol extract of Justicea. if you add justicia carnea leaves in avocado seed tea, you may just get yourself the best remedy for cardiovascular diseases. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives. Sedlak J, Lindsay RH. Two of the most important soil considerations include fertility and drainage. However, watch out for nematodes and spider mites. This claim have not been verified. Too much fertilizer is damaging for your plant. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. The plume flowers grow atop a crown of foliage in large dense clusters. The leaves are also rich source of vitamin A, vitamin C, and vitamin E. Another plant with this composition is pumpkin fruit. Consumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. Phytother Res 2011;25(3):444-450. . It has been reported previously that under certain conditions, dietary antioxidants such as ascorbic acid, tocopherol and carotenoids could act, occasionally, as pro-oxidants to initiate slight degree of oxidative stress microenvironment. The lush foliage and distinctive flowers make Brazilian Plume a natural for a . Bottom Line. The result from the kidney histology could be due to the presence of active secondary metabolites and daily dosing of the extract. 1983;53:27589. He has B.Sc.,and M.Sc. Some people would rather chew the leaves, while others add to meals or brew into a tea (in combination with other plants). Akintimehin, E.S., Karigidi, K.O., Omogunwa, T.S. Chanda S, Parekh J, Vaghasiya Y, Dave R, Baravalia Y, Nair R. Medicinal plants - from traditional use to toxicity assessment: a review. Total protein concentration in tissue homogenates were determined using biuret method Tietz [16]. Philadelphia: WB. Article The antioxidants in Justicia carnea helps protect the liver and the heart from toxic agents and free radicals. Whether added to garden beds or pots, the justicia (plant) adds a colorful tropical touch and are easy to grow. Google Scholar. At the end of 14th day of administration, rats were allowed to fast overnight, sacrificed to collect samples for biochemical analysis and histopathological examination. While every effort has been made to describe these plants accurately, please keep in mind that height, bloom time, and color may differ in various climates. View abstract. 1978;52:30210. Microsomal lipid peroxidation. Tietz NW. During the growing season, the justicia (plant) should be watered thoroughly with room temperature water. OTHER NAME(S): Achille Millefeuille, Achille Mille-Feuille, Ana. From mild to severe order, the graded doses showed distorted renal cortex with collapsed renal glomeruli and dillated capsular spaces. The plant looks great along garden borders and near building foundations. 3 . List of various diseases cured by Justicia Betonica. et al. Despite the therapeutic importance of medicinal plants, toxic substances have been shown to be present in large numbers of plants investigated [3]. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. 2. Article The ability of glutathione to regenerate these dietary antioxidants has been linked to the redox state of glutathione disulphide-glutathione couple (GSSG/GSH) ratio [31]. I am a practicing medical doctor, a philosopher, critical thinker, a globalist, a patriot, SEO expert and a patient blogger. statement and Relative to the control, liver of rats treated with doses of J. carnea ethanol extract showed varied degree of hepatic injury in a dose dependent manner. After 72h of soaking, the wine (dark purplish red) colored filtrate was filtered using a double cheese cloth, concentrated under reduced pressure using rotary evaporator and subsequently water bath at 40C to obtain a slurry (dark purple) extract termed Justicia carnea ethanol extract (JCEE). J. Pharmacogn. No. It has been shown also that other specie of justicia improve central nervous system functions and health and protect it from toxic damages. Technical guidelines assembly of veterinary medicine research. Despite the use of Justicia carnea and other reported scientific studies, there are no reports on its effects on the major organs of the body. This later condition is termed insulin resistance. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. J Ethnopharmacol 1999;64(3):265-270. The flowering Justicia plant is a perennial native to the Atlantic Forest eco-regions in eastern Brazil. The principle is based on the reduction of dichromate in a weak acid medium (acetic acid) to chromic acetate which is further heated in the presence of hydrogen peroxide to form an unstable intermediate (perchromic acid) that can be monitored spectrophotometrically at 620nm. The cuttings are taken from the parent plant in the spring after the plant has bloomed. International Journal of Biochemistry Research & Review. These compounds beyond boosting your blood concentration, thereby enhancing the transport of nutrients to various parts of the body, also boost your immune system against several infectious diseases. Great for use as a foundation or mass planting, it is also terrific for containers or as a houseplant. Side effects of Ewe eje (Justicia carnea leaf Side Effects). Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. Control treatment showed normal central venules without congestion, the morphology of the hepatocytes appear normal, the sinusoids appear normal with no observable form of infiltration and no observable pathological lesion seen. J Am Diet Assoc. In this study, the aqueous leaf extract of Justicia carnea was used. All analyzed dataset to support the conclusions of this article is included as tables in the uploaded supplementary files. The flowers are slightly fragrant and mostly sterile. 2002;82:197205. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. Briefly, 1.0ml of the sample was mixed with 2ml of TCA-TBA-HCl reagent (0.37% thiobarbituric acid, 15% trichloroacetic acid and 0.24N HCl in 1:1:1) and boiled at 100C in a water bath for 15min. It is not. Rats that received 50 and 100mg/kg body weight JCEE showed significant (p<0.05) increase in liver weight while other doses showed no significant difference compared to the control. These tropical plants are not very fussy about soil. One of the side-effects of some orthodox drugs used in the past had been excessive inhibition of the carbohydrate-hydrolyzing enzymes, which in turn leads to abdominal discomfort and. Phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis indicated presence of . Acta Scientiarum Polonorum, Technologia Alimentaria. 2016;5(1):6270 https://doi.org/10.1016/j.joad.2015.08.006. Safety assessment of oral administration of ethanol extract of, $$ \mathrm{Total}\ \mathrm{protein}\kern0.5em =\kern0.5em \frac{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{sample}}{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{standard}}\kern0.5em \times \kern0.5em \mathrm{Concentration}\ \mathrm{of}\ \mathrm{standard} $$, $$ \mathrm{Catalase}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}\right)=\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{SOD}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}/\mathrm{mg}\ \mathrm{protein}\right)\kern0.5em =\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{Concentration}\kern0.5em \mathrm{of}\kern0.5em \mathrm{reduced}\kern0.5em \mathrm{GSH}\kern0.5em =\kern0.5em \frac{\left(\Delta \mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\left(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}\right)} $$, $$ \mathrm{Malondialdehyde}\kern0.5em =\kern0.5em \frac{\left(\mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\Big(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, https://doi.org/10.1186/s40816-020-00234-4, https://doi.org/10.1016/j.jep.2015.06.005, https://doi.org/10.1016/j.joad.2015.08.006, https://doi.org/10.1016/j.jep.2005.06.013, https://doi.org/10.3109/08860220903367585, https://doi.org/10.1590/S0102-695X2011005000196, https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867, https://doi.org/10.35841/biomedicalresearch.30-18-666, https://doi.org/10.1016/j.jep.2007.02.011, https://doi.org/10.1186/s40816-019-0104-4, https://doi.org/10.1016/j.fitote.2008.02.005, https://doi.org/10.1016/j.jada.2008.06.430, https://doi.org/10.1016/j.biocel.2006.07.001, https://doi.org/10.1186/s12906-015-0760-y, http://creativecommons.org/licenses/by/4.0/. The liver and kidneys excised from all the experimental rats were fixed in a labeled sample bottles containing 10% formalin and processed for histological examination. Buege JA, Aust SD. Local consumers of the leaves are mostly . What this means is that aside fighting anemia, justicia carnea leaves also improves your cardiovascular health by suppressing the tendency for dyslipidemia. This research focused on the safety and in vivo antioxidant status of healthy albino rats exposed to J. carnea leaf ethanol extract. The hematopoietic systems represent a sensitive target of toxic compounds and an essential index of physiological and pathological status in experimental animals [24]. Turn off the heat and then soak the leaves into the pot. Hence, the use of Justicia carnea leaves may help reduce your risk of heart diseases, heart attack, stroke etc. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Terms and Conditions, Therefore,it is imperative to investigate the effects of the plant on the essential biochemical indices in diabetic rats so as to establish its safety. In its native habitat, the Justicia carnea plant grows upright and may reach 3 5 feet tall. Read also (Cashew leaves: health benefits and side effects of Anacardium occidentale). PubMed SOD activity was determined by its ability to inhibit the auto-oxidation of epinephrine determined by the increase in absorbance at 480nm. It is an awesome plant and worth your time and attention. The lush foliage and distinctive flowers make Brazilian Plume a natural for a tropical garden. Ashwagandha tea: 10 benefits, side effects and recipes, 7 interesting health facts about Black sapote fruits. 1. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. Data were analyzed using one-way analysis of variance (ANOVA) using Statistical Product and Service Solutions (SPSS) version 17.0 and results were expressed as meanSEM. However, caution should be taken as higher dose at 1200mg/kg could cause noticeable tissue injury. The in-vitro . The catalase activity was calculated using the expression: Note: A=change in absorbance, TV=total volume, TP=total protein, SV=sample volume, =molar extinction=40M1 cm1. Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. This study has confirmed the safety of ethanol extract of J. carnea leaf and validates its conventional use as blood booster. However, scientifically it is called Justicia carnea. Ewe eje as a Natural Blood booster/tonic: Due to the high concentration of iron in this leaf, it can help boost blood production by increasing the red blood cells, haemoglobin, and the blood platelets. Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. It may also affect the activity of hormones. In winter, you might have to spray the leaves with water, especially if the air is dry. How to make Ewe eje Extracthow to prepare justicia carnea. Justicia carnea, the Brazilian plume flower, Brazilian-plume, flamingo flower, or jacobinia, is a flowering plant in the family Acanthaceae. Elevated activity of catalase in liver and kidney across tested doses of J. carnea ethanol extract showed no significant effect compared to the control. It is commonly referred to as blood root, blood booster, ewe eje in Yoruba, Ogwu obara in Igbo, and jacobinia in Brazil and south America. [1] The perennial plant is native to the Atlantic Forest ecoregions of eastern Brazil . Olumese FE, Onoagbe IO, Eze GI, Omoruyi FO. They also maintain our skin tone and texture, and help in reproductive functions. Onyeabo, Chimaraoke & Achi, Ngozi & Chima, Ekeleme-Egedigwe & Ebere, Chidinma & Okoro, Chidinma. Absorbance reading was taken at 620nm regularly at an interval of 1min against reagent blank. 2004;19(12):16. Justicia carnea (Brazilian Plume) is an upright, evergreen shrub with large, dark green leaves, 10 in. 4. This post was last modified on January 2, 2023 5:23 pm. The aim of this study is to evaluate the effects of J. carnea leaf extract on hematology indices and organ antioxidant system in healthy wistar rats. It is cultivated and sold as a decorative potted plant and is planted in landscaping as a feature plant in warm . It has already been pointed out that this plant is used traditionally to boost blood production among the people of southern Nigeria. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. de Vries, J. X., Tauscher, B., and Wurzel, G. Constituents of Justicia pectoralis Jacq. Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. 10.17306/J.AFS.2017.0492. In a reaction mixture containing 0.01M phosphate buffer (pH7.0), 0.5ml of 0.2M H2O2 and 0.4ml distilled water, 0.5ml of sample was added. Beijing: Chemical Press; 2011. 3 The plants in the family are reported to have CNS effects which are exploited in the management of epilepsy, other mental disorders, headache and fever, probably due to their sedative and analgesic properties. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. Radhika J, Sathya S, Jothi G, Japasheba JL. The absorbance was read at 412nm against the reagent blank. Aim. I do hope that after reading through this article, you would plan to start cultivating this amazing plant specie in your garden. Extinction coefficient () of MDA TBA complex=1.56105M1cm1. Clinical Guide to Laboratory tests. The mixture was allowed to cool and centrifuged at 650g for 10min to obtain the supernatant. https://doi.org/10.3390/molecules191221442. However, further research needs to done to determine the mode of action of the plant, and it's effects on humans. The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats.

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